4-氟-2-硝基-N-甲基苯胺合成路线 （共 8 条）
反应条件
potassium carbonate in tetrahydrofuran; dichloromethane
T=20°C;
参考文献
RIES, Uwe; SIEGER, Peter
Patent: US2007/249595 A1, 2007 ;
Location in patent: Page/Page column 10 ;
反应条件
potassium carbonate in tetrahydrofuran; dichloromethane
T=20°C;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2007/203125 A1, 2007 ;
Location in patent: Page/Page column 37 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=120°C; 1.5 h; Inert atmosphere;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2258697 A1, 2010 ;
Location in patent: Page/Page column 75-76 ;
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in toluene
Ambient temperature;
参考文献
Brown, Samuel A.; Rizzo, Carmelo J.
Synthetic Communications, 1996 , vol. 26, # 21 p. 4065 - 4080
参考文献
Daszkiewicz; Kyziol
Polish Journal of Chemistry, 2003 , vol. 77, # 9 p. 1217 - 1220
反应条件
1: sat. NaHCO3 / CH2Cl2 / Ambient temperature
2: 92 percent / benzyltriethylammonium chloride, aq. NaOH / toluene / Ambient temperature
View Scheme
参考文献
Brown, Samuel A.; Rizzo, Carmelo J.
Synthetic Communications, 1996 , vol. 26, # 21 p. 4065 - 4080
反应条件
1: hydrogen / ethyl acetate / 4.5 h / 20 °C / 3750.38 Torr
2: tetrahydrofuran / 48 h / 20 °C
3: trichlorophosphate / 2 h / |Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Nickolaus, Peter
Patent: US2013/237527 A1, 2013 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol
P=3000.3 Torr;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2007/203125 A1, 2007 ;
Location in patent: Page/Page column 37 ;
