3-羟基-4-硝基苯甲醛合成路线 （共 21 条）
反应条件
sodium borohydride in ethanol
参考文献
ZENECA LIMITED; ZENECA Pharma S.A.
Patent: EP581464 A1, 1994 ;
EP 0581464 A1
参考文献
Lock
Chemische Berichte, 1929 , vol. 62, p. 1182
Chemische Berichte, 1933 , vol. 66, p. 1761,1762
反应条件
iodine; sodium carbonate; potassium iodide
参考文献
Henry; Sharp
Journal of the Chemical Society, 1924 , vol. 125, p. 1057
参考文献
Lock
Chemische Berichte, 1929 , vol. 62, p. 1182
Chemische Berichte, 1933 , vol. 66, p. 1761,1762
反应条件
Yield given. Multistep reaction;
参考文献
Gottsegen, Agnes; Nogradi, Mihaly; Vermes, Borbala; Kajtar-Peredy, Maria; Bihatsi-Karsai, Eva
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 315 - 320
反应条件
1: 92 percent / KF / dimethylformamide / 24 h / 60 °C
2: 64 percent / SnCl2*2H2O / ethanol / 0.5 h / 70 °C
View Scheme
参考文献
Belliotti, Thomas R.; Wustrow, David J.; Brink, Wouter A.; Zoski, Kim T.; Shih, Yu-Hsin; Whetzel, Steven Z.; Georgic, Lynn M.; Corbin, Ann E.; Akunne, Hyacinth C.; Heffner, Thomas G.; Pugsley, Thomas A.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5181 - 5187
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 5 h;
参考文献
Tokyo Institute of Technology; Kyoto University
Patent: EP2123637 A1, 2009 ;
Location in patent: Page/Page column 19 ;
参考文献
Zeegers, Petrus J.; Thompson, Malcolm J.
Magnetic Resonance in Chemistry, 1992 , vol. 30, # 6 p. 497 - 499
反应条件
2: 63 percent / pyridine / 24 h
3: 17 percent / Ph3P / NiCl2(Ph3P)2, Zn / dimethylformamide / 18 h
4: 1) NaOMe, 2) H2 / 2) palladium-charcoal / 1) methylene dichloride, methanol, 1h, 2) ethyl acetate, methanol
5: 91 percent / K2CO3 / acetone / 6 h / Heating
6: 100 percent / PBr3 / benzene / 80 °C
7: 15 percent / sodium, tetraphenylethene / tetrahydrofuran / 24 h
View Scheme
参考文献
Gottsegen, Agnes; Nogradi, Mihaly; Vermes, Borbala; Kajtar-Peredy, Maria; Bihatsi-Karsai, Eva
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 315 - 320
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
2: iron; ammonium chloride / ethanol; water / 2 h / 78 °C
View Scheme
参考文献
MSD OSS B.V.; BLACKABY, Wesley, Peter; DE KORT, Martin; ENTHOVEN, Mark; HINCHLIFFE, Paul, Stuart; PAULIE, Chris; TIMMERS, Cornelis, Marius; VERKAIK, Saskia
Patent: WO2013/41458 A1, 2013 ;
