3-(2-氟苯基)丙-2-炔酸合成路线 (共 4 条)
反应条件
1: With potassium carbonate; copper(l) chloride in N,N-dimethyl-formamide
T=20°C; P=760.051 Torr; 16 h;
2: With hydrogenchloride in dichloromethane; water
pH=1; Product distribution / selectivity;
参考文献
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; ZHANG, Yugen; YU, Dingyi
Patent: WO2011/75087 A1, 2011 ;
Location in patent: Page/Page column 17-18; 26 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine in N,N-dimethyl-formamide
T=20°C; Sonogashira coupling; 5 h; Inert atmosphere;
参考文献
Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252
参考文献
Solomon,I.J.; Filler,R.
Journal of the American Chemical Society, 1963 , vol. 85, p. 3492 - 3496
反应条件
potassium carbonate; L-proline; copper(I) bromide in dimethyl sulfoxide
T=100°C; 3 h; Inert atmosphere;
参考文献
Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252