trifluoroacetic acid in water T=50°C;

water; trifluoroacetic acid T=50°C; 1 h;

1: 91 percent / BF3*Et2O / CH2Cl2 / -78 °C 2: Hg(ClO4)2*3H2O, 6N HCl / H2O / 25 °C 3: 81 percent / 1.) MsCl, Et3N, DMAP; 2.) DBU / CH2Cl2 / 0 °C 4: 78 percent / CF3COOH, / H2O / 50 °C View Scheme

1: 88 percent / diisopropylamine, butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C 2: 65 percent / HCl / methanol / 1.5 h / Heating 3: 84 percent / methanesulphonyl chloride / pyridine / 24 h / Ambient temperature 4: 90 percent / trifluoroacetic acid, water / 1 h / 50 °C View Scheme

1: 86 percent / 1.5percent HCl / 1.5 h / Heating 2: 81 percent / CuSO4, conc. H2SO4 / 24 h / Ambient temperature 3: 87 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 4: 88 percent / diisopropylamine, butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C 5: 65 percent / HCl / methanol / 1.5 h / Heating 6: 84 percent / methanesulphonyl chloride / pyridine / 24 h / Ambient temperature 7: 90 percent / trifluoroacetic acid, water / 1 h / 50 °C View Scheme

1: 87 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 2: 88 percent / diisopropylamine, butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C 3: 65 percent / HCl / methanol / 1.5 h / Heating 4: 84 percent / methanesulphonyl chloride / pyridine / 24 h / Ambient temperature 5: 90 percent / trifluoroacetic acid, water / 1 h / 50 °C View Scheme

1: 84 percent / methanesulphonyl chloride / pyridine / 24 h / Ambient temperature 2: 90 percent / trifluoroacetic acid, water / 1 h / 50 °C View Scheme

1: 65 percent / HCl / methanol / 1.5 h / Heating 2: 84 percent / methanesulphonyl chloride / pyridine / 24 h / Ambient temperature 3: 90 percent / trifluoroacetic acid, water / 1 h / 50 °C View Scheme

1: 81 percent / CuSO4, conc. H2SO4 / 24 h / Ambient temperature 2: 87 percent / pyridinium chlorochromate / CH2Cl2 / 1 h 3: 88 percent / diisopropylamine, butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C 4: 65 percent / HCl / methanol / 1.5 h / Heating 5: 84 percent / methanesulphonyl chloride / pyridine / 24 h / Ambient temperature 6: 90 percent / trifluoroacetic acid, water / 1 h / 50 °C View Scheme

in hexadeuterioacetone Irradiation;