1-(异丙基磺酰基)-2-硝基苯合成路线 （共 6 条）
反应条件
1.1: hydrogen / palladium 10 on activated carbon / methanol / 6 h 2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / Cooling 2.2: 16 h / 20 °C View Scheme
参考文献
GATEKEEPER PHARMACEUTICALS, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/140338 A1, 2011 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol 6 h;
参考文献
GATEKEEPER PHARMACEUTICALS, INC.; GRAY, Nathanael, S.; ZHOU, Wenjun
Patent: WO2011/140338 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
反应条件
dihydrogen peroxide in acetic acid
1.) below 80 deg C, 80 min 2.) reflux, 2 h;
参考文献
Courtin, Alfred; Tobel, Hans-Rudolf von; Auerbach, Guenther
Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1412 - 1419
反应条件
1: 71.6 percent / 1.) NaOH / ethanol / 1.) 15 min 2.) reflux, 14 h
2: 73.6 percent / H2O2 / acetic acid / 1.) below 80 deg C, 80 min 2.) reflux, 2 h
View Scheme
参考文献
Courtin, Alfred; Tobel, Hans-Rudolf von; Auerbach, Guenther
Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1412 - 1419
反应条件
2: aq. H2O2, AcOH
View Scheme
参考文献
Cogolli,P. et al.
Journal of Organic Chemistry, 1979 , vol. 44, # 15 p. 2636 - 2642
反应条件
ethanol
Behandeln in Eisessig mit wss. H2O2;
参考文献
Baldwin; Robinson
Journal of the Chemical Society, 1932 , p. 1445,1448
