(S)-2-甲基-1,4-丁二醇合成路线 （共 57 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 17 h; Inert atmosphere; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C; 3 h;
参考文献
ARAGON PHARMACEUTICALS, INC.; KAHRAMAN, Mehmet; GOVEK, Steven, P.; NAGASAWA, Johnny, Y.; SMITH, Nicholas, D.
Patent: WO2011/156518 A2, 2011 ;
Location in patent: Page/Page column 105; 106 ;
WO 2011/156518 A2
反应条件
methanol; potassium carbonate T=20°C; 1 h;
参考文献
Kim, Youngju; Watanabe, Hidenori; Kim, Bieong-Kil; Seu, Young-Bae
Tetrahedron Asymmetry, 2011 , vol. 22, # 16-17 p. 1658 - 1661
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 5 h;
参考文献
Qabaja, Ghassan; Wilent, Jennifer E.; Benavides, Amanda R.; Bullard, George E.; Petersen, Kimberly S.
Organic Letters, 2013 , vol. 15, # 6 p. 1266 - 1269
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=24°C; 10 h;
参考文献
Lautens, Mark; Stammers, Timothy A.
Synthesis, 2002 , # 14 p. 1993 - 2012
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=55°C; 4 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3964 - 3967
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Feringa, Ben L.; Lange, Ben de; Jong, Johannes C. de
Journal of Organic Chemistry, 1989 , vol. 54, # 10 p. 2471 - 2475
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 1 h;
参考文献
Journal of the American Chemical Society, , vol. 122, # 19 p. 4608 - 4617
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Jansen; Feringa
Synthetic Communications, 1992 , vol. 22, # 9 p. 1367 - 1376
反应条件
1: 72 h / 120 °C 2: 83 percent / triethylamine, H2 / 10percent Pd/C / ethyl acetate / 12.5 h / 2068.6 Torr / Ambient temperature 3: 87 percent / lithium aluminum hydride / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 10 p. 2471 - 2475
反应条件
1: 72 h / 120 °C 2: 98 percent / triethylamine, H2 / 10percent Pd/C / ethyl acetate / 12.5 h / 2068.6 Torr / Ambient temperature 3: lithium aluminum hydride / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 10 p. 2471 - 2475
