(S)-2-甲基-1,4-丁二醇合成路线 （共 57 条）
反应条件
1: 98 percent / triethylamine, H2 / 10percent Pd/C / ethyl acetate / 12.5 h / 2068.6 Torr / Ambient temperature 2: lithium aluminum hydride / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 10 p. 2471 - 2475
反应条件
1: 83 percent / triethylamine, H2 / 10percent Pd/C / ethyl acetate / 12.5 h / 2068.6 Torr / Ambient temperature 2: 87 percent / lithium aluminum hydride / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 10 p. 2471 - 2475
反应条件
1: Raney Nickel 2: LiAlH4 (LAH) View Scheme
参考文献
Bulletin des Societes Chimiques Belges, , vol. 101, # 7 p. 627 - 640
反应条件
1.1: bromine / diethyl ether / 3 h / Heating 1.2: potassium hydroxide / diethyl ether; ethanol / 0.5 h / Heating 2.1: thionyl chloride / Heating 3.1: 51 percent / sodium hydride / toluene / 0 - 20 °C 4.1: 70 percent / hydrogen / Pd/C / toluene / 25 °C / 5250.42 Torr 5.1: 74 percent / LiAlH4 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 24 p. 3979 - 3988
反应条件
1: thionyl chloride / Heating 2: 51 percent / sodium hydride / toluene / 0 - 20 °C 3: 70 percent / hydrogen / Pd/C / toluene / 25 °C / 5250.42 Torr 4: 74 percent / LiAlH4 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 24 p. 3979 - 3988
反应条件
1: 51 percent / sodium hydride / toluene / 0 - 20 °C 2: 70 percent / hydrogen / Pd/C / toluene / 25 °C / 5250.42 Torr 3: 74 percent / LiAlH4 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 24 p. 3979 - 3988
反应条件
1: ethanol / 4 h / 20 °C 2: Raney Ni / ethanol / 12 h / 20 °C 3: 85 percent / LAH / diethyl ether / 6 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 55, # 8 p. 1505 - 1518
反应条件
1: <Rh((S)-(6,6'-dimethylbiphenyl,2,2'-diyl)-bis(diphenyldiphosphine)(8,9,10-norbornadiene)>BF4 / tetrahydrofuran / 40 h / 90 °C 2: 0.140 g / NaBH4 / methanol / 0.25 h / 0 °C 3: NaBH3CN / aq. formic acid View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, p. 1258 - 1275
反应条件
1: 24 percent / Pd(OAc)2, Ph3P / 15 h / Heating 2: <Rh((S)-(6,6'-dimethylbiphenyl,2,2'-diyl)-bis(diphenyldiphosphine)(8,9,10-norbornadiene)>BF4 / tetrahydrofuran / 40 h / 90 °C 3: 0.140 g / NaBH4 / methanol / 0.25 h / 0 °C 4: NaBH3CN / aq. formic acid View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, p. 1258 - 1275
反应条件
1: 84 percent / pyridine / DMAP / CH2Cl2 / 30 h / 0 - 20 °C 2: 76 percent / LiCl / dimethylformamide / 10 h / 70 °C 3: H2; Et3N / Pd-C / methanol / 12 h / 20 °C 4: 85 percent / LAH / diethyl ether / 6 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 55, # 8 p. 1505 - 1518
