(S)-2-甲基-1,4-丁二醇合成路线 （共 57 条）
反应条件
1: H2; Et3N / Pd-C / methanol / 12 h / 20 °C 2: 85 percent / LAH / diethyl ether / 6 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 55, # 8 p. 1505 - 1518
反应条件
1: <Rh((R)-(6,6'-dimethylbiphenyl-2,2'-diyl)-bis(diphenylphosphine)((Z,Z)-1,5-cyclooctadiene)>ClO4 / tetrahydrofuran / 48 h / 80 °C 2: NaBH3CN, HCl / aq. acetic acid / 3 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, p. 1258 - 1275
反应条件
1: Me3SiCl / 5 h / Heating 2: <Rh((R)-(6,6'-dimethylbiphenyl-2,2'-diyl)-bis(diphenylphosphine)((Z,Z)-1,5-cyclooctadiene)>ClO4 / tetrahydrofuran / 48 h / 80 °C 3: NaBH3CN, HCl / aq. acetic acid / 3 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, p. 1258 - 1275
反应条件
1: 39 percent / bis(dibenzylidenacetone)palladium, Ph3P, 1,2-bis(diphenylphosphine)ethane, AcOH / 20 h / Ambient temperature 2: Me3SiCl / 5 h / Heating 3: <Rh((R)-(6,6'-dimethylbiphenyl-2,2'-diyl)-bis(diphenylphosphine)((Z,Z)-1,5-cyclooctadiene)>ClO4 / tetrahydrofuran / 48 h / 80 °C 4: NaBH3CN, HCl / aq. acetic acid / 3 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 73, p. 1258 - 1275
反应条件
1.1: potassium hydroxide / toluene / 5 h / 110 °C 1.2: 16 h / |Reflux 2.1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 h 3.1: palladium hydroxide on carbon; hydrogen / ethyl acetate / 16 h / 20 °C 4.1: C50H73O4P / dichloromethane / 240 h / 5 °C / |Inert atmosphere 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 6 p. 1266 - 1269
反应条件
1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 h 2: palladium hydroxide on carbon; hydrogen / ethyl acetate / 16 h / 20 °C 3: C50H73O4P / dichloromethane / 240 h / 5 °C / |Inert atmosphere 4: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 6 p. 1266 - 1269
反应条件
1: palladium hydroxide on carbon; hydrogen / ethyl acetate / 16 h / 20 °C 2: C50H73O4P / dichloromethane / 240 h / 5 °C / |Inert atmosphere 3: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 6 p. 1266 - 1269
反应条件
1: C50H73O4P / dichloromethane / 240 h / 5 °C / |Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 6 p. 1266 - 1269
反应条件
lithium aluminium tetrahydride Reduction;
参考文献
Lin, Jing; Chan, Wing Hong; Lee, Albert W. M.; Wong, Wai Yeung; Huang, Pei Qiang
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2949 - 2951
反应条件
lithium aluminium tetrahydride in benzene
参考文献
Journal of Organic Chemistry, , vol. 27, p. 921 - 924
