(S)-2-甲基-1,4-丁二醇合成路线 （共 57 条）
反应条件
1.1: sodium perchromate dihydrate; sulfuric acid / water; acetone / 6 h / 20 °C / Cooling with ice 2.1: acetone / 12 h / 5 °C / Reflux 3.1: sulfuric acid / water 4.1: sulfuric acid / 3 h / Reflux 5.1: methanol / 2 h / 0 - 40 °C 6.1: hydrogenchloride; water / diethyl ether / 0.17 h 7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C 7.2: 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 1 p. 26 - 30
反应条件
1: pyridine / 5 h / 0 - 20 °C 2: Pseudomonas sp. lipase; water / 0.08 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 3: sodium hydroxide / water / 30 °C / pH 7.1 / Microbiological reaction; Yeast peptone dextrose broth; Enzymatic reaction 4: methanol; potassium carbonate / 1 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1658 - 1661
反应条件
1.1: sulfuric acid / benzene / 48 h / 70 °C 2.1: aluminium hydride / diethyl ether / -30 °C 2.2: -30 °C 3.1: pyridine / 5 h / 0 - 20 °C 4.1: Pseudomonas sp. lipase; water / 0.08 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 5.1: sodium hydroxide / water / 30 °C / pH 7.1 / Microbiological reaction; Yeast peptone dextrose broth; Enzymatic reaction 6.1: methanol; potassium carbonate / 1 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1658 - 1661
反应条件
1: Pseudomonas sp. lipase; water / 0.08 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 2: sodium hydroxide / water / 30 °C / pH 7.1 / Microbiological reaction; Yeast peptone dextrose broth; Enzymatic reaction 3: methanol; potassium carbonate / 1 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1658 - 1661
反应条件
1.1: aluminium hydride / diethyl ether / -30 °C 1.2: -30 °C 2.1: pyridine / 5 h / 0 - 20 °C 3.1: Pseudomonas sp. lipase; water / 0.08 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 4.1: sodium hydroxide / water / 30 °C / pH 7.1 / Microbiological reaction; Yeast peptone dextrose broth; Enzymatic reaction 5.1: methanol; potassium carbonate / 1 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 22, # 16-17 p. 1658 - 1661
反应条件
1: sodium periodate; osmium(VIII) oxide / water; acetone / 3.08 h / 0 - 22 °C / Inert atmosphere 2: sodium tetrahydroborate / methanol; dichloromethane / 0.33 h / -15 °C / Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 10 p. 2972 - 2977
反应条件
1: n-butyllithium; borane-ammonia complex; diisopropylamine / tetrahydrofuran / 2 h / 0 °C 2: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 18 h / 20 °C 3: sodium periodate; ruthenium(III) chloride*(x)H2O / tetrachloromethane; acetonitrile; water / 1 h / 20 °C 4: borane-THF / tetrahydrofuran / 3.5 h / 20 °C 5: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 2 p. 614 - 627
反应条件
1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 18 h / 20 °C 2: sodium periodate; ruthenium(III) chloride*(x)H2O / tetrachloromethane; acetonitrile; water / 1 h / 20 °C 3: borane-THF / tetrahydrofuran / 3.5 h / 20 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 2 p. 614 - 627
反应条件
1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 18 h / 20 °C 2: sodium periodate; ruthenium(III) chloride*(x)H2O / tetrachloromethane; acetonitrile; water / 1 h / 20 °C 3: borane-THF / tetrahydrofuran / 3.5 h / 20 °C 4: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 2 p. 614 - 627
反应条件
1: sodium periodate; ruthenium(III) chloride*(x)H2O / tetrachloromethane; acetonitrile; water / 1 h / 20 °C 2: borane-THF / tetrahydrofuran / 3.5 h / 20 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 2 p. 614 - 627
