1: 2-chloro-quinoline With copper(l) iodide; triethylamine; triphenylphosphine; palladium on activated charcoal in water T=25 - 30°C; 0.5 h; 2: hex-1-yne in water T=20 - 80°C; Sonogashira coupling; Further stages.;

copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine in water T=70°C; 6 h;

bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine T=20°C; Sonogashira coupling; 3 h;