(8Xi,13E,17Z)-11,15-二羟基-9-氧代前列腺-13,17-二烯-1-酸合成路线 （共 5 条）
反应条件
hydrogen fluoride in acetonitrile
0.666667 h; Ambient temperature;
参考文献
Okamoto; Kobayashi; Sato
Tetrahedron Letters, 1989 , vol. 30, # 33 p. 4379 - 4382
反应条件
1: 1.) n-BuLi, (2-thienyl)Cu(CN)Li / 1.) THF, -78 deg C; 2.) THF, -78 to 0 deg C, 1 h
2: 76 percent / (2-thienyl)Cu(CN)Li / tetrahydrofuran / -78 deg C up to 0 deg C
3: 87 percent / PPTS / propan-2-ol; diethyl ether / 5 h / Ambient temperature
4: 91 percent / Jones reagent / acetone; diethyl ether / 0.5 h / 0 °C
5: 89 percent / aq. HF / acetonitrile / 0.67 h / Ambient temperature
View Scheme
参考文献
Okamoto; Kobayashi; Sato
Tetrahedron Letters, 1989 , vol. 30, # 33 p. 4379 - 4382
反应条件
1: 1.) n-BuLi, (2-thienyl)Cu(CN)Li / 1.) THF, -78 deg C; 2.) THF, -78 to 0 deg C, 1 h
2: 76 percent / (2-thienyl)Cu(CN)Li / tetrahydrofuran / -78 deg C up to 0 deg C
3: 87 percent / PPTS / propan-2-ol; diethyl ether / 5 h / Ambient temperature
4: 91 percent / Jones reagent / acetone; diethyl ether / 0.5 h / 0 °C
5: 89 percent / aq. HF / acetonitrile / 0.67 h / Ambient temperature
View Scheme
参考文献
Okamoto; Kobayashi; Sato
Tetrahedron Letters, 1989 , vol. 30, # 33 p. 4379 - 4382
反应条件
1: 76 percent / (2-thienyl)Cu(CN)Li / tetrahydrofuran / -78 deg C up to 0 deg C
2: 87 percent / PPTS / propan-2-ol; diethyl ether / 5 h / Ambient temperature
3: 91 percent / Jones reagent / acetone; diethyl ether / 0.5 h / 0 °C
4: 89 percent / aq. HF / acetonitrile / 0.67 h / Ambient temperature
View Scheme
参考文献
Okamoto; Kobayashi; Sato
Tetrahedron Letters, 1989 , vol. 30, # 33 p. 4379 - 4382
反应条件
1: 91 percent / Jones reagent / acetone; diethyl ether / 0.5 h / 0 °C
2: 89 percent / aq. HF / acetonitrile / 0.67 h / Ambient temperature
View Scheme
参考文献
Okamoto; Kobayashi; Sato
Tetrahedron Letters, 1989 , vol. 30, # 33 p. 4379 - 4382
