1-溴-2-(二甲氧基甲基)-4,5-二甲氧基苯合成路线 （共 6 条）
反应条件
1: nBuLi / -78 °C 2: TosOH / benzene / 2 h / Heating 3: borane*Me2S / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Plaumann, Heinz P.; Smith, James G.; Rodrigo, Russell
Journal of the Chemical Society, Chemical Communications, 1980 , # 8 p. 354 - 355
反应条件
1: BuLi 2: aq. H2SO4 3: Na2Cr2O7 4: LDA / tetrahydrofuran / 1.) - 78 deg C, 2.) -78 deg C to r.t. 5: SOCl2, pyridine / tetrahydrofuran / 18 h / Ambient temperature 6: K2CO3 / acetone / 11 h / Heating View Scheme
参考文献
Kobayashi, Kazuhiro; Maeda, Kouji; Uneda, Tomokazu; Morikawa, Osamu; Konishi, Hisatoshi
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 4 p. 443 - 446
反应条件
1: With toluene-4-sulfonic acid in methanol
3 h; Heating / reflux;
2: With sodium methylate in methanol
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2007/40240 A1, 2007 ;
Location in patent: Page/Page column 26 ;
反应条件
trimethyl orthoformate in methanol
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US5969140 A1, 1999 ;
反应条件
1: nBuLi / -78 °C
2: TosOH / benzene / 2 h / Heating
3: borane*Me2S / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Plaumann, Heinz P.; Smith, James G.; Rodrigo, Russell
Journal of the Chemical Society, Chemical Communications, 1980 , # 8 p. 354 - 355
反应条件
n-butyllithium; iodine; acetic acid in tetrahydrofuran; ethyl acetate
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US5103023 A1, 1992 ;
