2'-脱氧-N-乙基-胞苷合成路线 （共 5 条）
参考文献
BERRY and ASSOCIATES, INC.; HODGES, John, C.; BERRY, Lana, L.
Patent: WO2012/75005 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1: With N,O-bis-(trimethylsilyl)-acetamide; Et3N-BH3 in tetrahydrofuran
T=25°C; Reduction; 3 h;
2: With ammonia in water
T=55°C; Hydrolysis; 12 h;
参考文献
Sergueeva, Zinaida A.; Sergueev, Dmitri S.; Shaw, Barbara Ramsay
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 1-2 p. 275 - 282
反应条件
in ethanol
T=55°C; 3.5 h;
参考文献
Kraszewski; Delort; Teoule
Tetrahedron Letters, 1986 , vol. 27, # 7 p. 861 - 864
反应条件
in ethanol
T=55°C; 432 h;
参考文献
Kraszewski; Delort; Teoule
Tetrahedron Letters, 1986 , vol. 27, # 7 p. 861 - 864
反应条件
1: 78 percent / dimethyldioxirane / acetone; CH2Cl2 / 25 °C
2: 63 percent / 2N methanol. NH3 / 25 °C
View Scheme
参考文献
Saladino, Raffaele; Mincione, Enrico; Crestini, Claudia; Mezzetti, Maurizio
Tetrahedron, 1996 , vol. 52, # 19 p. 6759 - 6780
