2-羟基-5-甲氧基苯乙酮合成路线 （共 63 条）
反应条件
air; basic hydrotalcite C13 T=150°C; 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Climent, M. J.; Corma, A.; Iborra, S.; Primo, J.
Journal of Catalysis, 1995 , vol. 151, # 1 p. 60 - 66
反应条件
sodium hydride in mineral oil T=0 - 100°C;
参考文献
Nolan, Karen A.; Doncaster, Jeremy R.; Dunstan, Mark S.; Scott, Katherine A.; Frenkel, A. David; Siegel, David; Ross, David; Barnes, John; Levy, Colin; Leys, David; Whitehead, Roger C.; Stratford, Ian J.; Bryce, Richard A.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7142 - 7156
反应条件
1: 55 percent / PhN(Me)MgBr / diethyl ether / 3 h / 20 °C 2: 95 percent / conc. HCl / 24 h / 20 °C 3: 74 percent / KOH / methanol / 0.5 h / Heating View Scheme
参考文献
Sosnovskikh; Kutsenko; Ovsyannikov
Russian Chemical Bulletin, 2000 , vol. 49, # 3 p. 478 - 481
反应条件
1: 90 °C 2: 64 percent / iodine / methanol / 25 °C View Scheme
参考文献
Lin; Hong
Journal of Organic Chemistry, 2001 , vol. 66, # 8 p. 2877 - 2880
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / -78 - 20 °C / |Inert atmosphere 1.2: -78 - 20 °C / |Inert atmosphere 2.1: hydrazine hydrate / methanol / 72 h / 20 °C View Scheme
参考文献
Fullam, Elizabeth; Talbot, James; Abuhammed, Areej; Westwood, Isaac; Davies, Stephen G.; Russell, Angela J.; Sim, Edith
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2759 - 2764
反应条件
1: in tetrahydrofuran T=20 - 25°C; 18 h; 2: With hydrogen; palladium 10 on activated carbon T=25°C; P=1018.63 Torr; 3: With hydrogenchloride; water T=20 - 25°C; 18 h;
参考文献
Roche Palo Alto LLC
Patent: US2007/49534 A1, 2007 ;
Location in patent: Page/Page column 32-33 ;
US 20070049534 A1
反应条件
palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide T=120°C; P=3750.38 Torr; 16 h; Autoclave;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2012 , vol. 18, # 40 p. 12595 - 12598
反应条件
1: 70.5 percent / pyridine / 0.5 h / 50 °C 2: 86 percent / KOH; pyridine / 0.25 h / 50 °C 3: 62.1 percent / H2SO4; glacial acetic acid / 1 h / Heating View Scheme
参考文献
Adam, Waldemar; Golsch, Dieter; Hadjiarapoglou, Lazaros
Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7292 - 7297
反应条件
1: sodium hydroxide / ethanol / 20 °C 2: copper(l) iodide; oxygen / 48 h / 50 °C / 760.05 Torr / Ionic liquid View Scheme
参考文献
Du, Zhiyun; Ng, Huifen; Zhang, Kun; Zeng, Huaqiang; Wang, Jian
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6930 - 6933
反应条件
1.1: sulfur; morpholine; p-toluenesulfonic acid / 8 h / 120 - 130 °C 1.2: 64 percent / sodium hydroxide; tetrabutylammonium bromide / H2O / 8 h / 100 °C 2.1: 85 percent / phosphorus oxychloride / 1,2-dichloro-ethane / 16 h / 20 °C 3.1: 66 percent / pyridine hydrochloride / 3 h / 180 - 190 °C View Scheme
参考文献
Venkateswarlu, Somepalli; Panchagnula, Gopala K.; Guraiah, Mothukuri Bala; Subbaraju, Gottumukkala V.
Tetrahedron, 2006 , vol. 62, # 42 p. 9855 - 9860
