3-乙炔基-α,α,α-三氟甲苯合成路线 (共 22 条)
反应条件
triethylamine in tetrahydrofuran
T=20°C; Cooling with ice;
参考文献
CV THERAPEUTICS, INC.
Patent: WO2009/94028 A1, 2009 ;
Location in patent: Page/Page column 55 ;
WO 2009/094028 A1
反应条件
1: 3-ethynyl-α,α,α,trifluorotoluene With n-butyllithium
2: chloroformic acid ethyl ester
参考文献
Durham, Robin; Mandel, Jeremie; Blanchard, Nicolas; Tam, William
Canadian Journal of Chemistry, 2011 , vol. 89, # 12 p. 1494 - 1505