1-氯甲基-3-三氟甲基苯合成路线 （共 50 条）
参考文献
Streitwieser,A. et al.
Journal of the American Chemical Society, 1970 , vol. 92, # 17 p. 5141 - 5150
反应条件
tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide T=0 - 10°C; electrolysis;
参考文献
d'Incan, Esther; Sibille, Soline; Perichon, Jacques; Moingeon, Marie-Odile; Chaussard, Jacques
Tetrahedron Letters, 1986 , vol. 27, # 35 p. 4175 - 4176
反应条件
Ni(bpy)(CH3SO3)2 in N,N-dimethyl-formamide T=20°C; Ionic liquidElectrochemical reaction;
参考文献
Barhdadi, Rachid; Maekawa, Hirofumi; Comminges, Clement; Troupel, Michel
Bulletin of the Chemical Society of Japan, 2009 , vol. 82, # 12 p. 1510 - 1513
反应条件
bis(1,5-cyclooctadiene)nickel (0); triethylsilyl trifluoromethanesulphonate; triethylamine; diphenylcyclohexyl phosphine in toluene T=20°C; Heck type reaction; P=760.051 Torr; 2 h;
参考文献
Matsubara, Ryosuke; Gutierrez, Alicia C.; Jamison, Timothy F.
Journal of the American Chemical Society, 2011 , vol. 133, # 47 p. 19020 - 19023
反应条件
1: (i) Na, KI, EtOH, (ii) /BRN= 743242/ 2: aq. HCl View Scheme
参考文献
Lednicer; Emmert
Journal of medicinal chemistry, 1968 , vol. 11, # 6 p. 1258 - 1262
反应条件
2: aq. H2SO4 View Scheme
参考文献
Kuentzel,H. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 868 - 897
反应条件
in dimethyl sulfoxide
参考文献
PFIZER INC.
Patent: EP259085 B1, 1991 ;
反应条件
standard free energy changes investigated; Thermodynamic data;
参考文献
Chemistry Letters, , p. 1047 - 1050
反应条件
sodium acetate in ethanol; dimethyl sulfoxide
参考文献
FMC Corporation
Patent: US5536725 A1, 1996 ;
反应条件
in dimethyl sulfoxide
参考文献
PFIZER INC.
Patent: EP259085 A1, 1988 ;
EP 0259085 A1
