4-乙炔基-α,α,α-三氟甲苯合成路线 （共 50 条）
反应条件
1: sodium hydroxide / toluene / 72 h / 130 °C 2: zinc dibromide / toluene / 24 h / 130 °C View Scheme
参考文献
Cano, Rafael; Yus, Miguel; Ramon, Diego J.
Tetrahedron, 2012 , vol. 68, # 5 p. 1393 - 1400
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine T=20°C; 0.75 h;
参考文献
Thomas; Souza; Marder
Journal of the Chemical Society, Dalton Transactions, 2001 , # 10 p. 1650 - 1656
反应条件
palladium diacetate; acetic acid; silver carbonate in dimethyl sulfoxide; N,N-dimethyl-formamide T=120°C; 0.833333 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 77, # 12 p. 5381 - 5388
反应条件
1: copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine; t-Bu3PH*BPh4 / acetonitrile / 24 h / 60 °C / Inert atmosphere 2: palladium diacetate; acetic acid; silver carbonate / dimethyl sulfoxide; N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere View Scheme
参考文献
Shibahara, Fumitoshi; Dohke, Yoshimasa; Murai, Toshiaki
Journal of Organic Chemistry, 2012 , vol. 77, # 12 p. 5381 - 5388
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; pentane
T=25°C; 2 h; Inert atmosphere;
参考文献
Truong, Thanh; Daugulis, Olafs
Organic Letters, 2011 , vol. 13, # 16 p. 4172 - 4175
反应条件
CuI(xantphos); caesium carbonate in N,N-dimethyl-formamide
T=135°C; Sonogashira type reaction; 0.5 h; Inert atmosphereMicrowave irradiation;
参考文献
Tsai, Wen-Ting; Lin, Yun-Yung; Wang, Yu-Jen; Lee, Chin-Fa
Synthesis, 2012 , vol. 44, # 10 p. 1507 - 1510
反应条件
bis-triphenylphosphine-palladium(II) chloride; oxygen in 1,4-dioxane
T=80°C; Sonogashira type coupling; 18 h;
参考文献
Wang, Xuan; Qin, Weiwei; Kakusawa, Naoki; Yasuike, Shuji; Kurita, Jyoji
Tetrahedron Letters, 2009 , vol. 50, # 46 p. 6293 - 6297
反应条件
tert.-butylnitrite; trifuran-2-yl-phosphane; palladium diacetate; acetic acid in dimethyl sulfoxide
T=20 - 32°C; Sonogashira coupling; 16 h; Inert atmosphere;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Chemical Communications, 2011 , vol. 47, # 28 p. 7959 - 7961
反应条件
sodium tetrachloropalladium (II); copper(l) iodide; tri-tert-butyl phosphine; diisopropylamine
T=80°C; Sonogashira coupling; Inert atmosphere;
参考文献
Schilz, Marc; Plenio, Herbert
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2798 - 2807
反应条件
copper(I)-USY zeolite; air in N,N-dimethyl-formamide
T=110°C; 15 h;
参考文献
Chassaing, Stefan; Alix, Aurelien; Boningari, Thirupathi; Sido, Karim Sani Souna; Keller, Murielle; Kuhn, Philippe; Louis, Benoit; Sommer, Jean; Pale, Patrick
Synthesis, 2010 , # 9 art. no. Z27909SS, p. 1557 - 1567
