1: 77 percent / butyl-lithium / tetrahydrofuran 2: 75 percent 3: 92 percent / 1.) ozone, 2.) hydrogen peroxide, formic acid 4: 8 percent / 1.) NaBH4, 2.) trifluoroacetic anhydride / 1.) NaBH4, ethanol, 2.) trifluoroacetic anhydride, benzene 5: 55 percent / KOH / tetrahydrofuran; H2O; dimethylsulfoxide / 1.) aq. KOH, THF, room temperatures, 20h, 2.) DMSO, 50 deg. C, 1h View Scheme

1: 92 percent / 1.) ozone, 2.) hydrogen peroxide, formic acid 2: 8 percent / 1.) NaBH4, 2.) trifluoroacetic anhydride / 1.) NaBH4, ethanol, 2.) trifluoroacetic anhydride, benzene 3: 55 percent / KOH / tetrahydrofuran; H2O; dimethylsulfoxide / 1.) aq. KOH, THF, room temperatures, 20h, 2.) DMSO, 50 deg. C, 1h View Scheme

1: 75 percent 2: 92 percent / 1.) ozone, 2.) hydrogen peroxide, formic acid 3: 8 percent / 1.) NaBH4, 2.) trifluoroacetic anhydride / 1.) NaBH4, ethanol, 2.) trifluoroacetic anhydride, benzene 4: 55 percent / KOH / tetrahydrofuran; H2O; dimethylsulfoxide / 1.) aq. KOH, THF, room temperatures, 20h, 2.) DMSO, 50 deg. C, 1h View Scheme

1: 8 percent / 1.) NaBH4, 2.) trifluoroacetic anhydride / 1.) NaBH4, ethanol, 2.) trifluoroacetic anhydride, benzene 2: 55 percent / KOH / tetrahydrofuran; H2O; dimethylsulfoxide / 1.) aq. KOH, THF, room temperatures, 20h, 2.) DMSO, 50 deg. C, 1h View Scheme

1: 77 percent / butyl-lithium / tetrahydrofuran 2: 75 percent 3: 92 percent / 1.) ozone, 2.) hydrogen peroxide, formic acid 4: 8 percent / 1.) NaBH4, 2.) trifluoroacetic anhydride / 1.) NaBH4, ethanol, 2.) trifluoroacetic anhydride, benzene 5: 55 percent / KOH / tetrahydrofuran; H2O; dimethylsulfoxide / 1.) aq. KOH, THF, room temperatures, 20h, 2.) DMSO, 50 deg. C, 1h View Scheme

1: KOH / tetrahydrofuran; H2O 2: KOH / dimethylsulfoxide / 50 °C View Scheme

potassium hydroxide in tetrahydrofuran; water; dimethyl sulfoxide 1.) aq. KOH, THF, room temperatures, 20h, 2.) DMSO, 50 deg. C, 1h;

1: 80 percent / toluene 2: 77 percent / butyl-lithium / tetrahydrofuran 3: 75 percent 4: 92 percent / 1.) ozone, 2.) hydrogen peroxide, formic acid 5: 8 percent / 1.) NaBH4, 2.) trifluoroacetic anhydride / 1.) NaBH4, ethanol, 2.) trifluoroacetic anhydride, benzene 6: 55 percent / KOH / tetrahydrofuran; H2O; dimethylsulfoxide / 1.) aq. KOH, THF, room temperatures, 20h, 2.) DMSO, 50 deg. C, 1h View Scheme

(methylation);