7-羟基-2(1H)-喹啉酮合成路线 （共 12 条）
反应条件
AlCl3, aluminium chloride in chlorobenzene T=0 - 120°C;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
Location in patent: Page/Page column 50 ;
WO 2012/003418 A2
反应条件
aluminium trichloride in chlorobenzene T=120°C; 2 h;
参考文献
Yang, Zheng-Yu; Xia, Yi; Xia, Peng; Brossi, Arnold; Lee, Kuo-Hsiung
Tetrahedron Letters, 1999 , vol. 40, # 24 p. 4505 - 4506
反应条件
pyridine; AlCl3 in dichloromethane; ethyl acetate
反应条件
sodium hydroxide in water 1.5 h;
参考文献
Chen, Yeh-Long; Wang, Tai-Chi; Fang, Kuo-Chang; Chang, Nein-Chen; Tzeng, Cherng-Chyi
Heterocycles, 1999 , vol. 50, # 1 p. 453 - 462
反应条件
acetic acid in acetic acid Substitution; 3 h; Heating;
参考文献
Abd El-Aal; Koraierm
Journal of the Chinese Chemical Society, 2000 , vol. 47, # 2 p. 389 - 395
反应条件
1: 95 percent 2: 70 percent / AlCl3 / chlorobenzene View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 24 p. 4505 - 4506
反应条件
1: 24 percent / 2 h / Heating 2: 90 percent / 1.0 N NaOH / H2O / 1.5 h View Scheme
参考文献
Heterocycles, , vol. 50, # 1 p. 453 - 462
反应条件
1: 40 percent / KOH / propan-2-ol / 20 h / Heating 2: 76 percent / 1.) NaI; 2.) triethylamine / acetonitrile / 1.) 4 h, reflux; 2.) 4 h, reflux View Scheme
参考文献
Banno; Fujioka; Kikuchi; Oshiro; Hiyama; Nakagawa
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4377 - 4388
反应条件
potassium carbonate in ethanol Reflux;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
Location in patent: Page/Page column 65 ;
WO 2012/003418 A2
反应条件
1: 29 percent / K2CO3 / dimethylformamide / 4 h / 60 °C 2: 51 percent / NaI, Et3N / acetonitrile / 4 h / Heating View Scheme
参考文献
Chen, Xin; Sassano, Maria F.; Zheng, Lianyou; Setola, Vincent; Chen, Meng; Bai, Xu; Frye, Stephen V.; Wetsel, William C.; Roth, Bryan L.; Jin, Jian
Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7141 - 7153
