1-氯-3,5-二甲氧基苯合成路线 （共 65 条）
反应条件
Yield given. Multistep reaction;
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; 2-methoxy-6-(N-methyl-N-phenyl-amino)phenyl(dicyclohexyl)phosphine; caesium carbonate T=90°C; 12 h; Inert atmosphereSchlenk techniqueSealed tube;
参考文献
Li, Pengbin; Lue, Bo; Fu, Chunling; Ma, Shengming
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 7 p. 1255 - 1259
反应条件
potassium acetate; tris(dibenzylideneacetone)dipalladium (0) in 1,4-dioxane T=110°C; 3 h;
参考文献
Billingsley, Kelvin L.; Barder, Timothy E.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 28 p. 5359 - 5363
反应条件
1.1: palladium diacetate; potassium iodide; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; triethylamine / ethyl acetate / 16 h / 50 °C / |Inert atmosphere; |Schlenk technique 2.1: methanol / ethyl acetate / 1 h / -5 - 20 °C / |Inert atmosphere; |Schlenk technique 2.2: 4 h / 20 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Guerrand, Helene D. S.; Marciasini, Ludovic D.; Jousseaume, Melissa; Vaultier, Michel; Pucheault, Mathieu
Chemistry - A European Journal, 2014 , vol. 20, # 19 p. 5573 - 5579
反应条件
t-BuXPhos Pd(II) phenethylamine chloride; lithium hexamethyldisilazane in tetrahydrofuran T=20°C; 2 h; Inert atmosphere;
参考文献
Lee, Brian K.; Biscoe, Mark R.; Buchwald, Stephen L.
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3672 - 3674
反应条件
trichlorophosphate T=0 - 100°C; 2.5 h; Reflux;
参考文献
ANACOR PHARMACEUTICALS, INC.; GLAXOSMITHKINE LLC; XIA, Yi; ALLEY, Michael, Richard Kevin; ZHOU, Yasheen; SINGH, Rajeshwar; DING, Charles; CAO, Kathy; PLATTNER, Jacob, J.; OU, Ligong; JIA, Guofeng; SARASWAT, Neerja; RAMACHANDRAN, Sreekanth; ZHOU, Ding
Patent: WO2011/17125 A1, 2011 ;
Location in patent: Page/Page column 113 ;
反应条件
trichlorophosphate T=40 - 50°C; Vilsmeier reaction;
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
BrettPhos Palladacycle; sodium t-butanolate; hydrazine in tetrahydrofuran T=20°C; 0.025 h; Flow reactorSonicationInert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 12 p. 3434 - 3437
Angew. Chem., , vol. 125, # 12 p. 3518 - 3521,4
反应条件
sodium carbonate; bis(dibenzylideneacetone)-palladium(0); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in 1,4-dioxane; water Suzuki-Miyaura cross-coupling; 48 h; Inert atmosphereReflux;
参考文献
Murai, Norio; Yonaga, Masahiro; Tanaka, Keigo
Organic Letters, 2012 , vol. 14, # 5 p. 1278 - 1281
反应条件
sodium thiomethoxide in 1-methyl-pyrrolidin-2-one T=20 - 140°C;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD.
Patent: WO2007/149033 A1, 2007 ;
Location in patent: Page/Page column 68-69 ;
WO 2007/149033 A1
