1-氯-3,5-二甲氧基苯合成路线 （共 65 条）
反应条件
1: 1.) Mg; 2.) I2 / 1.) THF, reflux, 36 h; 2.) THF, 2 h
2: 89 percent / HI / 3 h / Heating
View Scheme
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
反应条件
C18H16Cl2O4Pd2; caesium carbonate; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl in N,N-dimethyl-formamide
T=120°C; 24 h; Inert atmosphere;
参考文献
Alacid, Emilio; Najera, Carmen
Journal of Organic Chemistry, 2009 , vol. 74, # 21 p. 8191 - 8195
反应条件
magnesium; ethylene dibromide; dilithium tetrachlorocuprate
1.) THF, reflux 6 h, 2.) THF, 0 deg C 90 min, 20 deg C 16 h; Yield given. Multistep reaction;
参考文献
Novak; Salemink
Synthesis, 1983 , vol. No. 7, p. 597 - 598
反应条件
magnesium; ethylene dibromide; dilithium tetrachlorocuprate
1.) THF, reflux 6 h, 2.) THF, 0 deg C 90 min, 20 deg C 16 h; Yield given. Multistep reaction;
参考文献
Novak; Salemink
Synthesis, 1983 , vol. No. 7, p. 597 - 598
反应条件
magnesium; ethylene dibromide; dilithium tetrachlorocuprate
1.) THF, reflux 6 h, 2.) THF, 0 deg C 90 min, 20 deg C 16 h; Yield given. Multistep reaction;
参考文献
Novak; Salemink
Synthesis, 1983 , vol. No. 7, p. 597 - 598
