(Z)-3-(吡咯烷-1-基)2-丁酸乙酯合成路线 （共 16 条）
反应条件
in dichloromethane T=20°C; 0.5 h;
参考文献
Zhu, Shizheng; Jin, Guifang; Xu, Yong
Tetrahedron, 2003 , vol. 59, # 24 p. 4389 - 4394
反应条件
triethylamine in ethanol Ambient temperature; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 779 - 781
参考文献
Acta Crystallographica, Section C: Crystal Structure Communications, , vol. 52, # pt 10 p. 2513 - 2515
反应条件
1: (Z)-3-pyrrolidin-1-yl-but-2-enoic acid ethyl ester; 1,4-trans-dibromo-2-butene
2: hydrolysis;
3: decarboxylation;
参考文献
Holland, Joanne M.; Lewis, Mark; Nelson, Adam
Angewandte Chemie - International Edition, 2001 , vol. 40, # 21 p. 4082 - 4084
反应条件
1: 4-Pyridinecarboxaldehyde oxime With pyridine; N-chloro-succinimide in chloroform
T=20°C; 0.5 h;
2: (Z)-3-pyrrolidin-1-yl-but-2-enoic acid ethyl ester With triethylamine in chloroform
T=50°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1408042 A1, 2004 ;
Location in patent: Page 30 ;
EP 1408042 A1
反应条件
potassium acetate in ethanol
T=25°C; 6 h;
参考文献
Alberola, A.; Calvo, L. A.; Ortega, A. Gonzalez; Sadaba, M. L.; Sanudo, M. C.
Anales de Quimica, 1995 , vol. 91, # 3-4 p. 284 - 289
