(5-溴-1H-吲唑-3-基)甲醇合成路线 （共 6 条）
反应条件
manganese(IV) oxide in ethyl acetate T=20°C;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0366 ;
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene
T=-78 - 0°C; 3.3 h;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1582211 A1, 2005 ;
Location in patent: Page/Page column 26 ;
EP 1582211 A1
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene
T=-10 - 20°C;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0365 ;
反应条件
sodium tetrahydroborate in methanol; water
T=0 - 20°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/80382 A1, 2007 ;
Location in patent: Page/Page column 134-135 ;
WO 2007/080382 A1
反应条件
1: sulfuric acid / 3 h / |Reflux
2: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C
View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
反应条件
1.1: sodium hydroxide / water / 1 h / 50 °C
1.2: 1 h / |Cooling with ice
1.3: 20 °C
2.1: sulfuric acid / 3 h / |Reflux
3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C
View Scheme
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
