反应条件
1: (+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol With potassium hydroxide in N,N-dimethyl-formamide T=0 - 5°C; 1.5 h; 2: sodium salt of the chloroacetic acid T=0 - 5°C; 1.5 h; 3: T=30 - 35°C;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC.
Patent: WO2004/50647 A2, 2004 ;
Location in patent: Page 19 ;