6-甲氧基吲哚-3-甲醛合成路线 （共 19 条）
反应条件
trichlorophosphate T=20°C; 2.5 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4541 - 4549
反应条件
tert.-butylhydroperoxide; Cl2Ru*(x)H2O; 2-oxo-3,3-dimethyl-butanoic acid in N-methyl-acetamide T=25°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 133, # 31 p. 11924 - 11927
反应条件
1: 94 percent / xylene / Heating 2: 99 percent / aq. NaOH / Heating 3: 87 percent / Cu; quinoline / Heating 4: 89 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -10 °C 1.2: tetrahydrofuran; hexane / 3 h / 0 °C 2.1: 6.4 g / NBS / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 3.2: pentane; tetrahydrofuran / 0.25 h / -78 °C 4.1: 190 mg / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
反应条件
1: 72 percent / methanol / -10 °C 2: 94 percent / xylene / Heating 3: 99 percent / aq. NaOH / Heating 4: 87 percent / Cu; quinoline / Heating 5: 89 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 87 percent / Cu; quinoline / Heating 2: 89 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 99 percent / aq. NaOH / Heating 2: 87 percent / Cu; quinoline / Heating 3: 89 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 6.4 g / NBS / tetrahydrofuran; hexane / 3 h / -78 °C 2.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 2.2: pentane; tetrahydrofuran / 0.25 h / -78 °C 3.1: 190 mg / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
反应条件
1.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 1.2: pentane; tetrahydrofuran / 0.25 h / -78 °C 2.1: 190 mg / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
参考文献
Journal of the Chemical Society, , vol. 121, p. 1896
