6-甲氧基吲哚-3-甲醛合成路线 （共 19 条）
反应条件
sodium hydride 1.) THF, 40 deg C, 90 min, 2.) THF, RT, 18 h; Yield given. Multistep reaction;
参考文献
Allen; Hamaker; La Loggia; Cook
Synthetic Communications, 1992 , vol. 22, # 14 p. 2077 - 2102
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C;
参考文献
Montagne, Cyril; Fournet, Guy; Joseph, Benoit
Synthesis, 2005 , # 1 art. no. T08504SS, p. 136 - 146
反应条件
DAHP; acetic acid; 1-nitro-propane Condensation; dehydration; 16 h; Heating;
参考文献
Jiang, Biao; Gu, Xiao-Hui
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 2 p. 363 - 371
反应条件
CH3I in water; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US6228877 B1, 2001 ;
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate T=20°C;
参考文献
Venkatanarayana; Dubey
Journal of Chemical Sciences, 2011 , vol. 123, # 5 p. 609 - 614
反应条件
sodium tetrahydroborate in methanol; formamide
参考文献
Kwon, Tae Hoon; Yoon, Ik Hwan; Shin, Ji-Sun; Lee, Young Hun; Kwon, Bong Jin; Lee, Kyung-Tae; Lee, Yong Sup
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2571 - 2574
反应条件
1: 6-methoxy-1H-indole-3-carboxaldehyde With sodium hydroxide in dichloromethane
T=20°C;
2: 4methoxybenzenesulfonyl chloride in dichloromethane
T=20°C;
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 20 °C
1.2: 97 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 91 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 80 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: NaOH / CH2Cl2 / 20 °C
1.2: 97 percent / CH2Cl2 / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
2.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
2.3: 78 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 85 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
