3-氨基-2-异丙基-4(3H)-喹唑啉酮合成路线 （共 5 条）
参考文献
Atkinson, Robert S.; Barker, Emma; Sutcliffe, Michael J.
Chemical Communications, 1996 , # 9 p. 1051 - 1052
反应条件
1: With pyridine in tetrahydrofuran
Heating / reflux;
2: With hydrazine in tetrahydrofuran
T=0 - 20°C; 4 h;
参考文献
NEUROSEARCH A/S
Patent: WO2007/104717 A1, 2007 ;
Location in patent: Page/Page column 19 ;
WO 2007/104717 A1
反应条件
sodium hydroxide in methanol
1 h; Heatingfurther reagent: aq. HCl;
参考文献
Smith; El-Hiti; Abdel-Megeed; Abdo
Journal of Organic Chemistry, 1996 , vol. 61, # 2 p. 647 - 655
反应条件
hydrazine hydrate in ethanol
16 h; Heating;
参考文献
Atkinson, Robert S.; Edwards, Paul J.; Thomson, Gordon A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 21 p. 3209 - 3216
反应条件
1: 78 percent / 2.5 h / 100 °C
2: 92 percent / hydrazine hydrate / ethanol / 16 h / Heating
View Scheme
参考文献
Atkinson, Robert S.; Edwards, Paul J.; Thomson, Gordon A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 21 p. 3209 - 3216
