3,5-二氯-4-吡啶-羧酰胺合成路线 （共 5 条）
反应条件
trichlorophosphate T=100°C; 4 h;
参考文献
Dai, Yujia; Hartandi, Kresna; Soni, Niru B.; Pease, Lori J.; Reuter, David R.; Olson, Amanda M.; Osterling, Donald J.; Doktor, Stella Z.; Albert, Daniel H.; Bouska, Jennifer J.; Glaser, Keith B.; Marcotte, Patrick A.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 386 - 390
反应条件
1: With oxalyl dichloride; N,N-dimethyl-formamide in benzene
T=20°C;
2: With hydroxylamine in diethylene glycol dimethyl ether; water
参考文献
Dai, Yujia; Hartandi, Kresna; Michaelides, Michael R.
Patent: US2006/178378 A1, 2006 ;
Location in patent: Page/Page column 16 ;
US 20060178378 A1
反应条件
ammonium hydroxide in tetrahydrofuran
参考文献
Dai, Yujia; Hartandi, Kresna; Soni, Niru B.; Pease, Lori J.; Reuter, David R.; Olson, Amanda M.; Osterling, Donald J.; Doktor, Stella Z.; Albert, Daniel H.; Bouska, Jennifer J.; Glaser, Keith B.; Marcotte, Patrick A.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 386 - 390
反应条件
lithium ethanolate in ethanethiol
T=-30 - 50°C;
参考文献
De Munno, Angela; Bertini, Vincenzo; Picci, Nevio; Iemma, Francesca; Pocci, Marco
Heterocycles, 1996 , vol. 43, # 9 p. 1893 - 1900
反应条件
1: lithium ethoxide / ethanol / -10 °C
2: lithium ethoxide / C2H5SH / -30 - 50 °C
View Scheme
参考文献
De Munno, Angela; Bertini, Vincenzo; Picci, Nevio; Iemma, Francesca; Pocci, Marco
Heterocycles, 1996 , vol. 43, # 9 p. 1893 - 1900
