反-4-氯-β-硝基苯乙烯合成路线 （共 30 条）
反应条件
1: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C -> room temp. 2: H2, 8percent NH3 / Raney Nickel / ethanol / 750.06 Torr 3: 61 percent / 36percent aq. HCl / 15 h / Heating View Scheme
参考文献
Hall
Synthesis, 1989 , # 6 p. 442 - 443
反应条件
1: acetophenone With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h; Inert atmosphere;
2: 4-Cl β-NO2 styrene in tetrahydrofuran
Michael addition; 3 h; Inert atmosphereCooling;
3: With ammonium chloride in tetrahydrofuran; water
Inert atmosphere;
参考文献
Jiang, Xianxing; Zhang, Yifu; Chan, Albert S. C.; Wang, Rui
Organic Letters, 2009 , vol. 11, # 1 p. 153 - 156
反应条件
titanium tetrachloride; zinc
1.) methylene chloride, -40 deg C -> room temperature, 2.) room temperature, 1 h; Yield given. Multistep reaction;
参考文献
Kim, Dae Young; Oh, Dong Young
Synthetic Communications, 1987 , vol. 17, # 8 p. 953 - 958
反应条件
1: 33 percent / LiAlH4 / tetrahydrofuran
2: 22 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
1: 33 percent / LiAlH4 / tetrahydrofuran
2: 22 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
3: 53 percent / dimethylformamide / 30 h / 100 °C
4: 11 percent / polyphosphoric acid / 2 h / 145 °C
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
triethylamine
0.5 h; Heating;
参考文献
Arora, P. K.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. <B> 20, # 11 p. 951 - 954
反应条件
triethylamine
18 h; Ambient temperature;
参考文献
Rao, Takkellapati Sudhakar; Deshpande, Shubhada; Mathur, Hari Har; Irivedi, Girish Kumar
Heterocycles, 1984 , vol. 22, # 9 p. 1943 - 1946
反应条件
1: 55 percent / benzene / 20 h / 20 °C
2: 92 percent / conc. hydrochloric acid / 10 h / Heating
View Scheme
参考文献
Rossi, Elisabetta; Sassano, Silvia; Stradi, Riccardo
Synthesis, 1986 , # 9 p. 765 - 766
反应条件
formic acid; [(η5-C5Me5)2Rh2(μ-Cl)2Cl2]; triethylamine; N-(2-amino-ethyl)-4-methyl-benzenesulphonamide in ethyl acetate
T=28°C; 2 h; chemoselective reaction;
参考文献
Xiang, Jing; Sun, Er-Xiao; Lian, Chun-Xia; Yuan, Wei-Cheng; Zhu, Jin; Wang, Qiwei; Deng, Jingen
Tetrahedron, 2012 , vol. 68, # 24 p. 4609 - 4620
反应条件
1.1: Takamoto's catalist / toluene / 24 h / 20 °C / Inert atmosphere
2.1: hydrogen / nickel / isopropyl alcohol; toluene / 71 °C / 3750.38 Torr / Inert atmosphere
3.1: hydrogenchloride; water / 1,2-dichloro-benzene / 24 h / 100 °C
3.2: 70 - 111 °C
View Scheme
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: US2011/152572 A1, 2011 ;
