(2R)-四氢-5-氧代-2beta-呋喃甲醛合成路线 （共 19 条）
反应条件
sodium tetrahydroborate in methanol T=-30 - -15°C; 1 h; Yield given;
参考文献
Bernard, Angela M.; Frongia, Angelo; Piras, Pier P.; Secci, Francesco
Organic Letters, 2003 , vol. 5, # 16 p. 2923 - 2926
反应条件
sodium methylsulfinylmethanide 1.) THF, 0 deg C, 1 h, 2a.) DMF, -40 deg C, 2 h, 2b.) RT, overnight; Yield given. Multistep reaction;
参考文献
Chattopadhyay, S.; Mamdapur, V. R.; Chadha, M. S.
Synthetic Communications, 1990 , vol. 20, # 9 p. 1299 - 1303
反应条件
hydrogen; Pd-BaSO4 in toluene
T=50°C; 20 h;
参考文献
Albrecht, Wolfgang; Tressl, Roland
Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1391 - 1396
反应条件
sodium periodate in dichloromethane; water
T=0°C; 0.5 h;
参考文献
Bernard, Angela M.; Frongia, Angelo; Piras, Pier P.; Secci, Francesco
Organic Letters, 2003 , vol. 5, # 16 p. 2923 - 2926
反应条件
1: 95 percent / H2, AcONa / 10percent Pd/C / tetrahydrofuran / 24 h / Ambient temperature
2: 80percent aq. acetic acid / 8 h / 50 °C
3: 0.65 M aq. NaOIO4, SiO2 / CH2Cl2 / 0.25 h
View Scheme
参考文献
Rassu, Gloria; Zanardi, Franca; Battistini, Lucia; Gaetani, Enrico; Casiraghi, Giovanni
Journal of Medicinal Chemistry, 1997 , vol. 40, # 2 p. 168 - 180
反应条件
1: SOCl2 / 4 h / Heating
2: H2 / 5percent Pd/BaSO4 / toluene / 20 h / 50 °C
View Scheme
参考文献
Albrecht, Wolfgang; Tressl, Roland
Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1391 - 1396
反应条件
1: SOCl2 / 4 h / Heating
2: H2 / 5percent Pd/BaSO4 / toluene / 20 h / 50 °C
View Scheme
参考文献
Albrecht, Wolfgang; Tressl, Roland
Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1391 - 1396
反应条件
1: 89.9 percent / NaNO2, aq. HCl / Ambient temperature
2: SOCl2 / 4 h / Heating
3: H2 / 5percent Pd/BaSO4 / toluene / 20 h / 50 °C
View Scheme
参考文献
Albrecht, Wolfgang; Tressl, Roland
Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1391 - 1396
反应条件
1: NaNO2, aq. HCl / Ambient temperature
2: SOCl2 / 4 h / Heating
3: H2 / 5percent Pd/BaSO4 / toluene / 20 h / 50 °C
View Scheme
参考文献
Albrecht, Wolfgang; Tressl, Roland
Tetrahedron: Asymmetry, 1993 , vol. 4, # 6 p. 1391 - 1396
反应条件
sodium periodate; silica gel in dichloromethane; water
T=20°C;
参考文献
Nakada, Masahisa; Takano, Masashi; Iwata, Yukitaka
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 10 p. 1581 - 1585
