2-(5-甲基噻吩-2-基)乙酸合成路线 （共 4 条）
反应条件
hydrogenchloride
Heating;
参考文献
Degenhardt, Charles R.
Synthetic Communications, 1982 , vol. 12, # 6 p. 415 - 422
反应条件
1: ammonium polysulfide; dioxane / 160 °C
2: aqueous KOH-solution
View Scheme
参考文献
Blanchette; Brown
Journal of the American Chemical Society, 1951 , vol. 73, p. 2779
Journal of the American Chemical Society, 1952 , vol. 74, p. 1066
参考文献
Abbott Laboratories
Patent: US5486525 A1, 1996 ;
反应条件
1.1: sodium hydride / toluene / 1 h
1.2: 1 h / 50 °C
2.1: hydrogenchloride; water / 0.5 h / Reflux
View Scheme
参考文献
O'Boyle, Niamh M.; Greene, Lisa M.; Bergin, Orla; Fichet, Jean-Baptiste; McCabe, Thomas; Lloyd, David G.; Zisterer, Daniela M.; Meegan, Mary J.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 7 p. 2306 - 2325
