hydrogen; Pd-BaSO4 in water; N,N-dimethyl-formamide 24 h;

1: 75 percent / diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature 2: trifluoroacetic acid / 0.67 h 3: diisopropylethylamine, 1-hydroxybenzotriazole / dimethylformamide / 12 h / Ambient temperature 4: trifluoroacetic acid / 0.67 h 5: diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature View Scheme

1: trifluoroacetic acid / 0.67 h 2: diisopropylethylamine, 1-hydroxybenzotriazole / dimethylformamide / 12 h / Ambient temperature 3: trifluoroacetic acid / 0.67 h 4: diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature View Scheme

1: 75 percent / diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature 2: trifluoroacetic acid / 0.67 h 3: diisopropylethylamine, 1-hydroxybenzotriazole / dimethylformamide / 12 h / Ambient temperature 4: trifluoroacetic acid / 0.67 h 5: diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature View Scheme

1: diisopropylethylamine, 1-hydroxybenzotriazole / dimethylformamide / 12 h / Ambient temperature 2: trifluoroacetic acid / 0.67 h 3: diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature View Scheme

1: trifluoroacetic acid / 0.67 h 2: diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature View Scheme

N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide 12 h; Ambient temperature; Yield given;