1,4-二氢-2,6-二甲基-4-苯基-3,5-吡啶羧酸二甲酯合成路线 （共 23 条）
反应条件
ammonium hydroxide in ethanol
2 h; Ambient temperature; Yields of byproduct given;
参考文献
Goerlitzer; Buss
Archiv der Pharmazie, 1981 , vol. 314, # 11 p. 938 - 949
反应条件
K-10 montmonirollite in toluene
T=110°C; 20 h;
参考文献
Balogh, Maria; Gacs-Baitz, Eszter; Simon, K.; Hermecz, I
ACH - Models in Chemistry, 1994 , vol. 131, # 3-4 p. 383 - 396
反应条件
1: With sulfuric acid
Hantzsch type condensation; 0.166667 h; Refluxneat (no solvent);
2: With ammonium acetate
Hantzsch type condensation; Refluxneat (no solvent);
参考文献
Alizadeh, Abdolali; Rostamnia, Sadegh
Synthesis, 2010 , # 23 art. no. Z21010SS, p. 4057 - 4060
反应条件
in ethanol
0.0833333 h; Irradiation;
参考文献
Khadilkar, B. M.; Chitnavis, A. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 7 p. 652 - 653
反应条件
pyridine; thionyl chloride in dichloromethane
other SOHal2, other heterocycles, other aldehydes; rate of formation;
参考文献
Eynde, Jean-Jaques Vanden; Anders, Ernst; Mayence, Annie; Maquestiau, Andre
Chemische Berichte, 1993 , vol. 126, # 5 p. 1251 - 1252
反应条件
bentonite K10 clay in ethanol
Heating;
参考文献
Eynde, Jean Jacques Vanden; Mayence, Annie; Lor, Pascal; Haverbeke, Yves Van
Bulletin des Societes Chimiques Belges, 1995 , vol. 104, # 6 p. 387 - 392
反应条件
potassium phosphate; ethylenediaminetetraacetic acid; Emulgen 911; human liver cytochrome b5; human liver HL 39 lipid extract; rabbit liver NADPH-P-450 reductase; yeast P-450 IIIA4; magnesium chloride in water
other human liver enzymes; Rate constant;
参考文献
Guengerich; Brian; Iwasaki; Sari; Baarnhielm; Berntsson
Journal of Medicinal Chemistry, 1991 , vol. 34, # 6 p. 1838 - 1844
反应条件
sodium nitrate; sulfuric acid
1) 0 to -8 deg C, 15 min; 2) 30 min; Yield given;
参考文献
Tirzit, G. D.; Skrastin'sh, I. P.; Dubur, G. Ya.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 1 p. 55 - 56
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , vol. 23, # 1 p. 68 - 69
反应条件
manganese(IV) oxide in dichloromethane
T=100°C; 0.0166667 h; microwave irradiation;
参考文献
Bagley, Mark C.; Lubinu, M. Caterina
Synthesis, 2006 , # 8 p. 1283 - 1288
反应条件
styrene; boron trifluoride diethyl etherate in chloroform
T=0 - 10°C; 3 h; Yield given;
参考文献
Hartman, George D.; Phillips, Brian T.; Halczenko, Wasyl; Springer, James P.; Hirshfield, Jordan
Journal of Organic Chemistry, 1987 , vol. 52, # 6 p. 1136 - 1139
