tetrabutyl-ammonium chloride; sodium formate; sodium carbonate; palladium diacetate in DMF (N,N-dimethyl-formamide) T=80°C; 0.5 h;

1.1: NaH / dimethylformamide; various solvent(s) / 0.17 h / 0 °C 1.2: dimethylformamide; various solvent(s) / 0.5 h / 0 - 20 °C 2.1: 6.3 g / HCO2Na; Na2CO3; TBACl / Pd(OAc)2 / dimethylformamide / 0.5 h / 80 °C View Scheme

1.1: ICl / CH2Cl2 / 3.5 h / Heating 2.1: NaH / dimethylformamide; various solvent(s) / 0.17 h / 0 °C 2.2: dimethylformamide; various solvent(s) / 0.5 h / 0 - 20 °C 3.1: 6.3 g / HCO2Na; Na2CO3; TBACl / Pd(OAc)2 / dimethylformamide / 0.5 h / 80 °C View Scheme