2-溴-1-(1-甲基-1H-吡唑-4-基)乙酮合成路线 （共 4 条）
反应条件
pyridinium tribromide in ethanol; dichloromethane
T=20°C; 3 h;
参考文献
Pfizer Inc.
Patent: US2012/214791 A1, 2012 ;
Location in patent: Page/Page column 21 ;
US 20120214791 A1
反应条件
1: 1-methyl-1H-pyrazole-4-carbonyl chloride With diazomethyl-trimethyl-silane in hexane; acetonitrile
T=0°C; 1 h;
2: hydrogen bromide With acetic acid in hexane; acetonitrile
T=20°C; 1.33333 h;
参考文献
ONO PHARMACEUTICAL CO., LTD.; COURTNEY, Steve; YARNOLD, Chris; FLANAGAN, Stuart; BRACE, Gareth; BARKER, John; ICHIHARA, Osamu; GADOULEAU, Elise; RICHARDSON, Anthony; KONDO, Takashi; IMAGAWA, Akira; NAKATANI, Shingo; SUZUKI, Ryo; KOUYAMA, Sho
Patent: WO2013/93484 A1, 2013 ;
Location in patent: Page/Page column 230; 231 ;
反应条件
1.1: thionyl chloride / 0.5 h / |Reflux
2.1: diazomethyl-trimethyl-silane / acetonitrile; hexane / 1 h / 0 °C
2.2: 1.33 h / 20 °C
View Scheme
参考文献
ONO PHARMACEUTICAL CO., LTD.; COURTNEY, Steve; YARNOLD, Chris; FLANAGAN, Stuart; BRACE, Gareth; BARKER, John; ICHIHARA, Osamu; GADOULEAU, Elise; RICHARDSON, Anthony; KONDO, Takashi; IMAGAWA, Akira; NAKATANI, Shingo; SUZUKI, Ryo; KOUYAMA, Sho
Patent: WO2013/93484 A1, 2013 ;
反应条件
1: tetrahydrofuran / 14 h / -78 - 20 °C
2: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 14 h / 80 °C
View Scheme
参考文献
BARTOLOZZI, Alessandra; CHEN, Zhidong; DINES, Jonathon Alan; LO, Ho Yin; LOKE, Pui Leng; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee M.
Patent: US2013/196967 A1, 2013 ;
