N-boc-1,2,3,6-四氢吡啶-4-羧酸合成路线 （共 11 条）
反应条件
lithium hydroxide in tetrahydrofuran T=20°C;
参考文献
Hanessian, Stephen; Yang, Gaoqiang; Rondeau, Jean-Michel; Neumann, Ulf; Betschart, Claudia; Tintelnot-Blomley, Marina
Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4544 - 4567
反应条件
sodium hydroxide in methanol
参考文献
Eli Lilly and Company
Patent: US6635657 B1, 2003 ;
US 6635657 B1
反应条件
triethylamine in 1,4-dioxane; water 24 h; Ambient temperature;
参考文献
Falch, Erik; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 285 - 289
反应条件
sodium hydroxide in 1,4-dioxane
反应条件
1: With lithium hydroxide monohydrate; N-benzyl-N,N,N-triethylammonium chloride; water in tert-butyl alcohol T=20°C; 48 h; 2: With hydrogenchloride in water T=0°C; pH=1;
参考文献
Vitnik; Ivanovic; Orevic; Zizak; Juranic
Synthetic Communications, 2009 , vol. 39, # 8 p. 1457 - 1471
反应条件
1: H2 / Pd/C / ethanol; H2O / 20 h / 2585.74 Torr 2: 2.2 g / NaHCO3; NaCl / CHCl3; H2O / 8 h / 70 °C 3: 96 percent / NaBH4 / ethanol / 3 h / 20 °C 4: 80 percent / 1,1'-(azodicarbonyl)dipiperidine; imidazole; PMe3 / CH2Cl2; toluene / 24 h / 20 °C 5: 98 percent / aq. LiOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 15 p. 4544 - 4567
反应条件
1: 2.2 g / NaHCO3; NaCl / CHCl3; H2O / 8 h / 70 °C 2: 96 percent / NaBH4 / ethanol / 3 h / 20 °C 3: 80 percent / 1,1'-(azodicarbonyl)dipiperidine; imidazole; PMe3 / CH2Cl2; toluene / 24 h / 20 °C 4: 98 percent / aq. LiOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 15 p. 4544 - 4567
反应条件
1: 80 percent / 1,1'-(azodicarbonyl)dipiperidine; imidazole; PMe3 / CH2Cl2; toluene / 24 h / 20 °C 2: 98 percent / aq. LiOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 15 p. 4544 - 4567
反应条件
1: 96 percent / NaBH4 / ethanol / 3 h / 20 °C 2: 80 percent / 1,1'-(azodicarbonyl)dipiperidine; imidazole; PMe3 / CH2Cl2; toluene / 24 h / 20 °C 3: 98 percent / aq. LiOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 15 p. 4544 - 4567
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; Heating / reflux;
参考文献
EP1176146 A1, ;
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