4-(5-氯-2-噻吩)-4-氧丁酸合成路线 （共 3 条）
参考文献
American Cyanamid Company
Patent: US4299769 A1, 1981 ;
US 4299769 A
反应条件
aluminium trichloride; nitrobenzene
参考文献
Buu-Hoi et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1083,1103
反应条件
1: 88 percent / N2H4*H2O / ethanol / 7 h / Heating
2: 86 percent / O2NC6H4SO3Na-m, NaOH / H2O; ethanol / 2 h / 100 °C
3: 58 percent / POCl3 / 1.5 h / 135 °C
4: 75 percent / N2H4*H2O / 3 h / Heating
View Scheme
参考文献
Steiner; Gries; Lenke
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 59 - 63
