1-异丙基-2-甲基-1H-吲哚合成路线 （共 4 条）
反应条件
1: Pd(PPh3)2Cl2, Et3N, CuI / dimethylformamide / 48 h / Ambient temperature
2: CuI / dimethylformamide / 4 h / Heating
3: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 8 h
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: CuI / dimethylformamide / 4 h / Heating
2: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 8 h
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
sodium hydride
1.) DMF, 1 h, 2.) DMF, 8 h; Yield given. Multistep reaction;
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
methyl-magnesium iodide; sodium hydride
1.) anisole, 2.) DMF, room temperature, 5 h; Yield given. Multistep reaction;
参考文献
Nilsson, Ingemar; Berg, Ulf; Sandstroem, Jan
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 6 p. 491 - 500
