1: With triethylamine in dichloromethane
T=0°C; 0.5 h;
2: With trifluoroacetic acid in dichloromethane
3 h;
3: With sodium hydrogencarbonate in dichloromethane; water
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2009/47161 A1, 2009 ;
Location in patent: Page/Page column 140 ;
