1: 83.5 percent / AlCl3 / CHCl3 / a) RT, overnight, b) reflux, 1 h 2: 70 percent / H2 / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr View Scheme

1: With sodium tetrahydroborate in ethylene glycol dimethyl ether T=0 - 20°C; 2 h; 2: With manganese(IV) oxide in acetone T=20°C; 18 h;

暂无反应条件数据

1.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C 1.2: ZnCl2 / tetrahydrofuran; hexane / 2 h / -78 - 20 °C 1.3: 84 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / 0 - 20 °C 2.1: 91 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C View Scheme

1: 83.5 percent / AlCl3 / CHCl3 / a) RT, overnight, b) reflux, 1 h 2: 70 percent / H2 / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr 3: 1.) conc. HCl, NaNO2, 2.) NaOAc / 1.) HOAc, H2O, 10 deg C, 30 min, 2.) HOAc, H2O, RT, 1 h 4: NaOAc / acetic acid; H2O / 2 h / 106 °C 5: 50percent H2SO4 / acetic acid; H2O / 2 h / Heating 6: 71 percent / mercaptoacetic acid / propionic acid / 1.3 h / 170 °C View Scheme