2-(2-溴苯基)-2-丙醇合成路线 （共 41 条）
反应条件
1: KHSO4 / Heating 2: NBS, (PhCOO)2 View Scheme
参考文献
Wender, Paul A.; Mucciaro, Thomas P.
Journal of the American Chemical Society, 1992 , vol. 114, # 14 p. 5878 - 5879
反应条件
1: α,α-dimethyl-(2-bromophenyl)methanol With n-butyllithium in tetrahydrofuran T=-78°C; 2 h; 2: tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 12 h; 3: With hydrogenchloride; water in tetrahydrofuran T=0 - 20°C; pH=< 5; 1 h;
参考文献
Cheung, Wing S.; Parks, Daniel J.; Parsons, William H.; Patel, Sharmila; Player, Mark R.
Patent: US2008/146637 A1, 2008 ;
Location in patent: Page/Page column 44 ;
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78 - -70°C; 2 h; 2: With tri-isopropoxy-borane in tetrahydrofuran T=20°C; Product distribution / selectivity;
参考文献
Player, Mark R.; Dax, Scott L.; Parsons, William H.; Brandt, Michael Richard; Calvo, Raul R.; Patel, Sharmila; Liu, Jian; Cheung, Wing S.; Jetter, Michele C.; Lee, Yu-Kai; Youngman, Mark A.; Pan, Wenxi; Weils, Kenneth M.; Beauchamp, Derek A.
Patent: US2007/259936 A1, 2007 ;
Location in patent: Page/Page column 168 ;
US 20070259936 A1
反应条件
palladium diacetate; caesium carbonate; triphenylphosphine in N,N-dimethyl-formamide T=120°C; 24 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 79, # 5 p. 2059 - 2074
反应条件
1.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal 2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere 2.2: 1 h / 20 - 40 °C 2.3: 20 - 30 °C 3.1: Pseudomonas cepacia lipase / tert-butyl methyl ether / 20 °C / Enzymatic reaction 4.1: palladium 10 on activated carbon; hydrogen / methanol View Scheme
参考文献
Serra, Stefano
Tetrahedron Asymmetry, 2011 , vol. 22, # 6 p. 619 - 628
反应条件
bis(benzonitrile)palladium(II) dichloride; caesium carbonate; P(3,5-2F3C-C6H3)3 in toluene T=110°C; 24 h; Inert atmosphereSchlenk technique; Reagent/catalyst;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
caesium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in toluene T=110°C; 24 h;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
dichloro bis(acetonitrile) palladium(II); caesium carbonate; P(3,5-2F3C-C6H3)3 in toluene T=110°C; 24 h; ConcentrationReagent/catalyst;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
palladium diacetate; caesium carbonate; P(3,5-2F3C-C6H3)3 in toluene T=110°C; 24 h; Reagent/catalyst;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
1: 67 percent / HCl / 5.5 h / 0 °C 2: 73 percent / butyllithium / tetrahydrofuran; hexane / 1 h / -100 °C View Scheme
参考文献
Parham, William E.; Bradsher, Charles K.; Reames, David C.
Journal of Organic Chemistry, 1981 , vol. 46, # 23 p. 4804 - 4806
