2-(2-溴苯基)-2-丙醇合成路线 （共 41 条）
反应条件
in diethyl ether
T=0 - 20°C; Inert atmosphere;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
in diethyl ether
16 h; Ambient temperature;
参考文献
Morrow, Gary W.; Chen, Ying; Swenton, John S.
Tetrahedron, 1991 , vol. 47, # 415 p. 655 - 664
反应条件
methyl-magnesium iodide
参考文献
American Hoechst Corporation
Patent: US3959475 A1, 1976 ;
反应条件
1.1: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.1: iodine; magnesium / diethyl ether / Inert atmosphere
2.2: 3 h / -10 °C / Inert atmosphere
2.3: Inert atmosphere
View Scheme
参考文献
Mahendar, Lodi; Krishna, Jonnada; Gopi Krishna Reddy, Alavala; Venkat Ramulu, Bokka; Satyanarayana, Gedu
Organic Letters, 2012 , vol. 14, # 2 p. 628 - 631
反应条件
1.1: iodine; magnesium / diethyl ether / Inert atmosphere
1.2: 3 h / -10 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.1: iodine; magnesium / diethyl ether / Inert atmosphere
3.2: 3 h / -10 °C / Inert atmosphere
3.3: Inert atmosphere
View Scheme
参考文献
Mahendar, Lodi; Krishna, Jonnada; Gopi Krishna Reddy, Alavala; Venkat Ramulu, Bokka; Satyanarayana, Gedu
Organic Letters, 2012 , vol. 14, # 2 p. 628 - 631
反应条件
1: in diethyl ether
T=25°C; Grignard reaction; 3 h; Reflux;
2: With sulfuric acid; water in diethyl ether
Cooling with ice;
参考文献
Prusek, Ondrej; Bures, Filip; Pytela, Oldrich
Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 1 p. 85 - 99
反应条件
bis(benzonitrile)palladium(II) dichloride; caesium carbonate; P(3,5-2F3C-C6H3)3 in toluene
T=110°C; 24 h; Inert atmosphereSchlenk technique;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
bis(benzonitrile)palladium(II) dichloride; caesium carbonate; P(3,5-2F3C-C6H3)3 in toluene
T=110°C; 24 h; Inert atmosphereSchlenk technique; Overall yield = 62 percent;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
bis(benzonitrile)palladium(II) dichloride; caesium carbonate; P(3,5-2F3C-C6H3)3 in toluene
T=110°C; 24 h; Inert atmosphereSchlenk technique;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
反应条件
bis(benzonitrile)palladium(II) dichloride; caesium carbonate; P(3,5-2F3C-C6H3)3 in toluene
T=110°C; 24 h; Inert atmosphereSchlenk technique; Overall yield = 62 percent;
参考文献
Iwasaki, Masayuki; Iino, Shohei; Nishihara, Yasushi
Organic Letters, 2013 , vol. 15, # 20 p. 5326 - 5329
