water; sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; toluene T=110°C; Suzuki cross-coupling; 16 h;

1: 3-methoxy-6-(methylthio)pyridazine With bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether in tetrahydrofuran 0.166667 h; Inert atmosphere; 2: C6H4ClIZn*ClLi in tetrahydrofuran T=25°C; 6 h; Inert atmosphere;

1.1: N,N-dimethyl-formamide / 24 h / 25 °C / Inert atmosphere 2.1: bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether / tetrahydrofuran / 0.17 h / Inert atmosphere 2.2: 6 h / 25 °C / Inert atmosphere View Scheme