(5-溴-2-甲氧基苄基)-二甲胺合成路线 （共 6 条）
反应条件
1: 1-bromo-4-methoxy-benzene With tert-butyl methyl ether; o-LiDMA in cyclohexane
T=55 - 60°C; 24 h; Inert atmosphere;
2: N,N-dimethylmethyleneammonium iodide in cyclohexane
参考文献
Slocum; Reece, Troy L.; Sandlin, Rebecca D.; Reinscheld, Thomas K.; Whitley, Paul E.
Tetrahedron Letters, 2009 , vol. 50, # 14 p. 1593 - 1595
反应条件
1: SOCl2 / CH2Cl2 / 2 h / 20 °C
2: 4.0 g / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1: 64 percent / NaBH4 / aq. ethanol
2: SOCl2 / CH2Cl2 / 2 h / 20 °C
3: 4.0 g / tetrahydrofuran / 18 h / 20 °C
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
in tetrahydrofuran
T=20°C; 18 h;
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1: With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; potassium carbonate in N,N-dimethyl-formamide
T=80°C;
2: With hydrogenchloride in N,N-dimethyl-formamide
1 h;
参考文献
LICA PHARMACEUTICALS A/S
Patent: WO2003/97575 A2, 2003 ;
Location in patent: Page/Page column 31 ;
反应条件
1: With potassium carbonate; palladium diacetate; 1,3-bis-(diphenylphosphino)propane in DMF (N,N-dimethyl-formamide); water
T=80°C;
2: With hydrogenchloride in DMF (N,N-dimethyl-formamide); water
1 h;
参考文献
LICA PHARMACEUTICALS A/S
Patent: WO2003/97574 A2, 2003 ;
Location in patent: Page/Page column 32 ;
