4-苯氧基-2,2,2-三氟苯乙酮合成路线 (共 7 条)
反应条件
1: 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne With tetrabutyl ammonium fluoride in tetrahydrofuran; diethyl ether T=-15°C; 0.166667 h; 2: 2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone in tetrahydrofuran; diethyl ether T=20°C; 1 h;
参考文献
Jeong, In Howa; Jeon, Sung Lan; Kim, Bum Tae
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7213 - 7216
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran; toluene
T=120°C; 30 h;
参考文献
Mann, Grace; Hartwig, John F.
Tetrahedron Letters, 1997 , vol. 38, # 46 p. 8005 - 8008
反应条件
1: trifluoroacetic acid With lithium hydroxide hydrate
T=5°C; 4 h;
2: 4-bromophenyl phenyl ether With iodine; magnesium in tetrahydrofuran
T=20 - 65°C; Grignard reaction;
3: With hydrogenchloride in tetrahydrofuran; water
T=20°C;
参考文献
Sun, Fei; Wang, Taipeng; Yang, Shiyong; Fan, Lin
Polymer, 2010 , vol. 51, # 17 p. 3887 - 3898
反应条件
sodium carbonate in dimethyl sulfoxide
参考文献
Science Union et Cie
Patent: US4288453 A1, 1981 ;
反应条件
aluminium trichloride in dichloromethane
T=0°C; 4 h;
参考文献
Keumi, Takashi; Shimada, Masakazu; Takahashi, Masahiro; Kitajima, Hidehiko
Chemistry Letters, 1990 , # 5 p. 783 - 786
反应条件
aluminium trichloride in dichloromethane
15 h; Ambient temperature;
参考文献
Simchen, Gerhard; Schmidt, Andreas
Synthesis, 1996 , # 9 p. 1093 - 1094
参考文献
Murata; Goto; Fujiyama; Mishima; Fujio; Tsuno
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 4 p. 1129 - 1137