2,2,2-三氟-1-呋喃-2-乙醇合成路线 （共 9 条）
反应条件
water; Dess-Martin periodane in dichloromethane T=20°C; 3 h;
参考文献
Schering Corporation
Patent: US2004/106794 A1, 2004 ;
Location in patent: Page 92 ;
US 20040106794 A1
反应条件
1: With cesium fluoride
T=20°C; 36 h; Heating / reflux;
2: With hydrogenchloride in water
4 h;
参考文献
Schering Corporation
Patent: US2004/106794 A1, 2004 ;
Location in patent: Page 91-92 ;
US 20040106794 A1
反应条件
tetrakis(dimethylamino)ethylene in N,N-dimethyl-formamide
T=-20 - 20°C; 8.16667 h; Irradiation;
参考文献
Ait-Mohand, Samia; Takechi, Naoto; Medebielle, Maurice; Dolbier Jr., William R.
Organic Letters, 2001 , vol. 3, # 26 p. 4271 - 4273
反应条件
tetrabutylammomium bromide in N,N-dimethyl-formamide
T=-10°C; 5 h; zinc rod anode, nickel cathode, 0.3 A;
参考文献
Sibille, S.; Mcharek, S.; Perichon, J.
Tetrahedron, 1989 , vol. 45, # 5 p. 1423 - 1428
反应条件
cesium fluoride in tetrahydrofuran
20 h; Heating;
参考文献
Motherwell, William B.; Storey, Lynda J.
Journal of Fluorine Chemistry, 2005 , vol. 126, # 4 p. 491 - 498
反应条件
potassium tert-butylate in tetrahydrofuran
参考文献
Surya Prakash; Jog, Parag V.; Batamack, Patrice T. D.; Olah, George A.
Science, 2012 , vol. 338, # 6112 p. 1324 - 1327
反应条件
zinc(II) chloride
T=120°C; Substitution; 24 h;
参考文献
Gong, Yuefa; Kato, Katsuya; Kimoto, Hiroshi
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 249 - 250
反应条件
toluene-4-sulfonic acid
Alkylation;
参考文献
Shirai, Kimihiro; Onomura, Osamu; Maki, Toshihide; Matsumura, Yoshihiro
Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5873 - 5876
反应条件
1: TBAF / tetrahydrofuran
2: 1 N aq. HCl / tetrahydrofuran
View Scheme
参考文献
Watanabe, Shoji; Fujita, Tsutomu; Sakamoto, Masami; Mino, Yasuhiro; Kitazume, Tomoya
Journal of Fluorine Chemistry, 1995 , vol. 73, # 1 p. 21 - 26
