2-氯-4-三氟甲氧基苯酚合成路线 （共 6 条）
反应条件
N,N-diisopropylmethyl amine; sulfuryl dichloride in toluene T=25°C; 2 h;
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
1.1: mCPBA 1.2: hydrolysis 2.1: SO2Cl2; diisobutylamine View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 14 p. 3347 - 3351
反应条件
1: Cs2CO3 / dimethylformamide / 5 h / 60 °C
2: triphenylphosphine; imidazole; iodine / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
1: Cs2CO3 / dimethylformamide / 6 h / 25 °C
2: diisobutylaluminum hydride / CH2Cl2 / 0.5 h / -78 - 25 °C
3: triphenylphosphine; imidazole; iodine / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=25°C; 6 h;
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
反应条件
1: Cs2CO3 / dimethylformamide / 6 h / 25 °C
2: diisobutylaluminum hydride / CH2Cl2 / 0.5 h / -78 - 25 °C
View Scheme
参考文献
Shi, Guo Q.; Dropinski, James F.; Zhang, Yong; Santini, Conrad; Sahoo, Soumya P.; Berger, Joel P.; MacNaul, Karen L.; Zhou, Gaochao; Agrawal, Arun; Alvaro, Raul; Cai, Tian-Quan; Hernandez, Melba; Wright, Samuel D.; Moller, David E.; Heck, James V.; Meinke, Peter T.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 17 p. 5589 - 5599
