(4-[(二甲基氨基)甲基]苯基)硼酸合成路线 (共 2 条)
反应条件
1: 1-(4-bromophenyl)-N,N-dimethylmethanamine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; 2: tributoxyborane in tetrahydrofuran T=-78 - 0°C; 1 h; 3: With water in tetrahydrofuran T=0°C;
参考文献
WO2007/18941 A2, ;
Page/Page column 58 ;
WO 2007/018941 A2
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=120°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/67119 A2, 2008 ;
Location in patent: Page/Page column 29; 39 ;
WO 2008/067119 A2