piperidine in ethanol
T=50°C; Knoevenagel condensation; Inert atmosphereReflux;
参考文献
Medda, Federico; Russell, Rupert J. M.; Higgins, Maureen; McCarthy, Anna R.; Campbell, Johanna; Slawin, Alexandra M. Z.; Lane, David P.; Lain, Sonia; Westwood, Nicholas J.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 9 p. 2673 - 2682
1: methanol / 1.5 h / 0 °C
2: 79 percent / sodium borohydride / methanol / 1) ice-cooling, 3 h; 2) room temperature, 24 h
View Scheme
参考文献
Asherson, Janet L.; Bilgic, Orhan; Young, Douglas W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3041 - 3047