2-(3,4-二甲氧基苯基)-2-甲基丙酸乙酯合成路线 （共 3 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran
T=-75°C; 18 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/56365 A2, 2004 ;
Location in patent: Page/Page column 159 ;
反应条件
sulfuric acid
12 h; Reflux;
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
Location in patent: Page/Page column 160-161 ;
WO 2010/093845 A1
反应条件
1: sulfuric acid; water / 7 h / Reflux
2: sulfuric acid / 12 h / Reflux
View Scheme
参考文献
EXELIXIS, INC.; BOLLU, Venkataiah; BOREN, Brant, Clayton; DALGARD, Jackline, Eve; FLATT, Brenton, T.; HAQ, Nadia; HUDSON, Sarah; MOHAN, Raju; MORRISSEY, Michael; PRATT, Benjamin; WANG, Tie-lin
Patent: WO2010/93845 A1, 2010 ;
WO 2010/093845 A1
